New Treatments For Arthritis Look Promising

khalid100

Minister (2k+ posts)

Joint replacement surgery for arthritis may not be needed in the future
A new molecule may allow patients to opt for a shot instead of joint replacement surgery in the future
https://news.usc.edu/136787/joint-replacement-surgery-for-arthritis-may-not-be-needed-in-the-future/

BY Cristy Lytal
MARCH 6, 2018
The ability to regenerate joint cartilage cells instead of surgically replacing joints would be a big boon for future patients; image shows microscopic view of joint cartilage cells. (Photo/Nancy Liu, Denis Evseenko Lab, USC Stem Cell)
Will there be a time when joint replacement surgery for arthritis could be avoided in favor of a shot? USC Stem Cell scientist Denis Evseenko has reason to be optimistic.
In a new publication in the Annals of Rheumatic Diseases, Evseenko’s team describes the promise of a new molecule named Regulator of Cartilage Growth and Differentiation, or RCGD 423 for short.
Discovered by the Evseenko team, the molecule enhances regeneration while curbing inflammation. When the scientists applied it to joint cartilage cells in the laboratory, these cells proliferated more and died less. When the scientists injected it into the knees of rats with damaged cartilage, the animals could more effectively heal their injuries.
RCGD 423 exerts its effects by communicating with a specific molecule in the body. This molecule, called the gp130 receptor, receives two very different types of signals: those that promote cartilage development in the embryo and those that trigger chronic inflammation in the adult. It amplifies the gp130 receptor’s ability to receive the developmental signals that can stimulate cartilage regeneration, while blocking the inflammatory signals that can lead to cartilage degeneration over the long term.
Given these auspicious early results, the team is already laying the groundwork for a clinical trial to test RCGD 423 or a similar molecule as a treatment for osteoarthritis or juvenile arthritis.
The goal is to make an injectable therapy for an early to moderate level of arthritis.
Denis Evseenko​
“The goal is to make an injectable therapy for an early to moderate level of arthritis,” said Evseenko, associate professor of orthopedic surgery and stem cell biology and regenerative medicine at the Keck School of Medicine of USC. “It’s not going to cure arthritis, but it will delay the progression of arthritis to the damaging stages when patients need joint replacements, which account for a million surgeries a year in the U.S.”
Evseenko sees RCGD 423 as a prototype for a new class of anti-inflammatory drugs with a broad range of indications. The lab has already developed several structural analogs of the molecule with varying biological effects and potency. His lab is partnering with scientists at USC and beyond to explore the broader potential of these molecules to treat rheumatoid arthritis, jaw arthritis, lupus, neurological and heart diseases and baldness, as well as to maintain pluripotent stem cells in the laboratory.


Gene Therapy for Rheumatoid Arthritis gets Approval to Start Clinical Trials
FROM THE CLINIC
Clara Rodríguez Fernández on 17/02/2017

https://labiotech.eu/arthrogen-gene-therapy-rheumatoid-arthritis/
Arthrogen-rheumatoid-arthritis-joint-gene-therapy.jpg

Arthrogen will start a Phase Ib trial for a gene therapy aiming to treat rheumatoid arthritis with a single injection and reduce costs for patients.
Arthrogen
, based in Amsterdam, is developing local gene therapies for inflammatory diseases. The biotech company has now announced it has received approval to start a Phase Ib trial with its lead candidate, ART-I02, in patients with rheumatoid arthritis who still suffer from inflamed joints despite multiple treatments.
The clinical trial will be conducted by the Centre for Human Drug Research (CHDR) in Leiden, with collaboration from other University Medical Centers in the Netherlands. Patients will start to be recruited in the first quarter of this year and results are expected by the end of 2018.

ART-I02 consists of a recombinant adeno-associated viral vector (rAAV) genetically engineered to encode the human interferon β (hIFN-β) protein, which has anti-inflammatory activity. By including an inflammation-inducible promoter in the genetic construct, the gene is only expressed when the patient suffers flares of acute pain and inflammation.

Founded in 2005 as a joint venture between the Dubai Bone & Joint Center (DBAJ) in the United Arab Emirates and the Academic Medical Center (AMC) in Amsterdam, Arthrogen has managed to raise almost €15M so far to support its pipeline for inflammatory disease.
One of the advantages of ART-I02 is that it’s delivered locally in the rheumatic joint, only affecting the target area to minimize side effects. In addition, gene therapy offers a long-lasting treatment with a single injection, which can significantly reduce costs for patients in the long term. However, Arthrogen will have to be careful to not follow the steps of its neighbor uniQure, whose first commercial gene therapy was a failure because of pricing issues.
Rheumatoid arthritis is a big market, expected to generate €32.5B ($34.6B) by 2020. The space is crowded, but by then blockbusters like top-seller Humira will no longer be protected by patents in both the US and Europe, leading the way for biosimilars and other options affordable in the long term such as gene therapy.
 

pak_aus

Senator (1k+ posts)
yar anybody tell us from where and how we can get this treatment or injections please if anybody can tell or teach us very urgently need this because my elderly father need this because he has lot of pain in his joints.
 

khalid100

Minister (2k+ posts)
yar anybody tell us from where and how we can get this treatment or injections please if anybody can tell or teach us very urgently need this because my elderly father need this because he has lot of pain in his joints.
The video says they've approved it in South Korea.
 
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Anuuge67

Chief Minister (5k+ posts)
yar anybody tell us from where and how we can get this treatment or injections please if anybody can tell or teach us very urgently need this because my elderly father need this because he has lot of pain in his joints.
Little early stages for this gene therapy.

The world’s first gene therapy for arthritis has been approved in Korea and US trials are due.

apply for a visa korea or UK.
 

Sohraab

Prime Minister (20k+ posts)
yar anybody tell us from where and how we can get this treatment or injections please if anybody can tell or teach us very urgently need this because my elderly father need this because he has lot of pain in his joints.

bhai meri mother ko bhi yehi bemari hai
 

eye-eye-PTI

Chief Minister (5k+ posts)
yar anybody tell us from where and how we can get this treatment or injections please if anybody can tell or teach us very urgently need this because my elderly father need this because he has lot of pain in his joints.
bhai meri mother ko bhi yehi bemari hai

یہ بیماری کسی کو بھی کسی بھی عمر میں ہو سکتی ہے ... الله سب کو تندرست و توانا رکھے اور کسی کا محتاج نہ بنائے ... آمین

مجھے ان انجیکشنز کا تو نہیں پتا کہاں سے ملیں گے لیکن اسلام آباد میں قائد اعظم انٹرنیشنل ہسپتال میں ایک ارتھیو پیڈک سرجن ہیں ڈاکٹر خالد اسلم ، وہ بہت اچھی تشخیص اور علاج کرتے اس مرض کا

میری پھوپھی زاد ہمشیرہ کا بہت مسلہ تھا اور کافی عرصے سے چلتا آ رہا تھا ، ان کا ہم نے تقریباً تمام چھوٹے بڑے ہسپتالوں سے علاج کروایا مگر کوئی فرق نہ پڑا ... کچھ ماہ قابل ڈاکٹر خالد اسلم کا کسی نے ریفرینس دیا ، وہاں گئے انہوں نے گھٹنے میں انجکشن لگائے تو اب ماشاللہ وہ بلکل ٹھیک ہیں ، چل پھر سکتی ہیں

یہ انجیکسشن ہے مہنگا مگر کام ٹھیک کرتا ہے

اگر ممکن ہو تو ان کو ایک دفع چیک کروا لیں شاید کچھ فرق پڑ جائے

ORTHOPEDIC SURGERY

ایک اور بات بھی بتا دوں اس مرض کا کوئی مستقل حل نہیں ہے ، کبھی کبھار یہ واپس بھی آ جاتا ہے لیکن زیادہ تر انجیکشنز سے ٹھیک ہو جاتا ہے

میں یہاں ایک میڈیکل رپورٹ کا انتظار کر رہا ہوں ، اس میں بھی کچھ ایسی ہی بیماری کا علاج درج ہو گا ... اگر مجھے مل گئی تو میں آپ کو انجکشن کا نام بھی بتا دوں گا جو یہاں یو کے میں چل رہا ہے
 

khalid100

Minister (2k+ posts)
یہ بیماری کسی کو بھی کسی بھی عمر میں ہو سکتی ہے ... الله سب کو تندرست و توانا رکھے اور کسی کا محتاج نہ بنائے ... آمین

مجھے ان انجیکشنز کا تو نہیں پتا کہاں سے ملیں گے لیکن اسلام آباد میں قائد اعظم انٹرنیشنل ہسپتال میں ایک ارتھیو پیڈک سرجن ہیں ڈاکٹر خالد اسلم ، وہ بہت اچھی تشخیص اور علاج کرتے اس مرض کا

میری پھوپھی زاد ہمشیرہ کا بہت مسلہ تھا اور کافی عرصے سے چلتا آ رہا تھا ، ان کا ہم نے تقریباً تمام چھوٹے بڑے ہسپتالوں سے علاج کروایا مگر کوئی فرق نہ پڑا ... کچھ ماہ قابل ڈاکٹر خالد اسلم کا کسی نے ریفرینس دیا ، وہاں گئے انہوں نے گھٹنے میں انجکشن لگائے تو اب ماشاللہ وہ بلکل ٹھیک ہیں ، چل پھر سکتی ہیں

یہ انجیکسشن ہے مہنگا مگر کام ٹھیک کرتا ہے

اگر ممکن ہو تو ان کو ایک دفع چیک کروا لیں شاید کچھ فرق پڑ جائے

ORTHOPEDIC SURGERY

ایک اور بات بھی بتا دوں اس مرض کا کوئی مستقل حل نہیں ہے ، کبھی کبھار یہ واپس بھی آ جاتا ہے لیکن زیادہ تر انجیکشنز سے ٹھیک ہو جاتا ہے

میں یہاں ایک میڈیکل رپورٹ کا انتظار کر رہا ہوں ، اس میں بھی کچھ ایسی ہی بیماری کا علاج درج ہو گا ... اگر مجھے مل گئی تو میں آپ کو انجکشن کا نام بھی بتا دوں گا جو یہاں یو کے میں چل رہا ہے
Thank you for the useful information brother. I myself suffer fro osteo arthritis.
No disrespect to doctor in Quaid-e-Azam hospital but in general there is no permanent cure to this disease. It is mainly genetic.
There two types of injections mainly for Arthritis as far as I know. In layman's language, one type is a steroid and the other type is kind of lubricant.
Steroid injection give you pain relief for a year or so but as you can understand effect the bones badly and other side effects.
Lubricants kind of help you with slowing down the damage to bones and joints etc.

The post I did above seems a new thing where they are targeting the genes to kind of reverse or slow down the disease.

Regarding Qaid-e-Azam international hospital, we had very bad experience in their A&E and I posted it few months ago as it happened with my elder sister. One of their specialist Orthopeadic doctor's was involved in it and we lost the trust totally. Moved our patient to CMH after that. You can read the details.
https://www.siasat.pk/forums/thread...zam-international-hospital-rawalpindi.614402/

But again each patient has different experience.

Anyway tx for your useful post.
 

pak_aus

Senator (1k+ posts)
یہ بیماری کسی کو بھی کسی بھی عمر میں ہو سکتی ہے ... الله سب کو تندرست و توانا رکھے اور کسی کا محتاج نہ بنائے ... آمین

مجھے ان انجیکشنز کا تو نہیں پتا کہاں سے ملیں گے لیکن اسلام آباد میں قائد اعظم انٹرنیشنل ہسپتال میں ایک ارتھیو پیڈک سرجن ہیں ڈاکٹر خالد اسلم ، وہ بہت اچھی تشخیص اور علاج کرتے اس مرض کا

میری پھوپھی زاد ہمشیرہ کا بہت مسلہ تھا اور کافی عرصے سے چلتا آ رہا تھا ، ان کا ہم نے تقریباً تمام چھوٹے بڑے ہسپتالوں سے علاج کروایا مگر کوئی فرق نہ پڑا ... کچھ ماہ قابل ڈاکٹر خالد اسلم کا کسی نے ریفرینس دیا ، وہاں گئے انہوں نے گھٹنے میں انجکشن لگائے تو اب ماشاللہ وہ بلکل ٹھیک ہیں ، چل پھر سکتی ہیں

یہ انجیکسشن ہے مہنگا مگر کام ٹھیک کرتا ہے

اگر ممکن ہو تو ان کو ایک دفع چیک کروا لیں شاید کچھ فرق پڑ جائے

ORTHOPEDIC SURGERY

ایک اور بات بھی بتا دوں اس مرض کا کوئی مستقل حل نہیں ہے ، کبھی کبھار یہ واپس بھی آ جاتا ہے لیکن زیادہ تر انجیکشنز سے ٹھیک ہو جاتا ہے

میں یہاں ایک میڈیکل رپورٹ کا انتظار کر رہا ہوں ، اس میں بھی کچھ ایسی ہی بیماری کا علاج درج ہو گا ... اگر مجھے مل گئی تو میں آپ کو انجکشن کا نام بھی بتا دوں گا جو یہاں یو کے میں چل رہا ہے
thanks brother lot to information how castly was that injection round about which took your sister ? and please share with us name also if find it, and please must share it.
 

Sohraab

Prime Minister (20k+ posts)
یہ بیماری کسی کو بھی کسی بھی عمر میں ہو سکتی ہے ... الله سب کو تندرست و توانا رکھے اور کسی کا محتاج نہ بنائے ... آمین

مجھے ان انجیکشنز کا تو نہیں پتا کہاں سے ملیں گے لیکن اسلام آباد میں قائد اعظم انٹرنیشنل ہسپتال میں ایک ارتھیو پیڈک سرجن ہیں ڈاکٹر خالد اسلم ، وہ بہت اچھی تشخیص اور علاج کرتے اس مرض کا

میری پھوپھی زاد ہمشیرہ کا بہت مسلہ تھا اور کافی عرصے سے چلتا آ رہا تھا ، ان کا ہم نے تقریباً تمام چھوٹے بڑے ہسپتالوں سے علاج کروایا مگر کوئی فرق نہ پڑا ... کچھ ماہ قابل ڈاکٹر خالد اسلم کا کسی نے ریفرینس دیا ، وہاں گئے انہوں نے گھٹنے میں انجکشن لگائے تو اب ماشاللہ وہ بلکل ٹھیک ہیں ، چل پھر سکتی ہیں

یہ انجیکسشن ہے مہنگا مگر کام ٹھیک کرتا ہے

اگر ممکن ہو تو ان کو ایک دفع چیک کروا لیں شاید کچھ فرق پڑ جائے

ORTHOPEDIC SURGERY

ایک اور بات بھی بتا دوں اس مرض کا کوئی مستقل حل نہیں ہے ، کبھی کبھار یہ واپس بھی آ جاتا ہے لیکن زیادہ تر انجیکشنز سے ٹھیک ہو جاتا ہے

میں یہاں ایک میڈیکل رپورٹ کا انتظار کر رہا ہوں ، اس میں بھی کچھ ایسی ہی بیماری کا علاج درج ہو گا ... اگر مجھے مل گئی تو میں آپ کو انجکشن کا نام بھی بتا دوں گا جو یہاں یو کے میں چل رہا ہے

bhai eye eye PTI , yeh jis injection ka aap zikar kar rahr hain , yeh injection DR ne meri ammi ko lagwane ke liye bohut baar kaha hai lekin meri ammi ke dil main aik khauff baith gaya hai ke agar main ne injection lagwa liye to mujhe koi side effect ho jai , main aap ki post ka screen shot le kar ammi ko read kerwaon ga , shukria bhai , Allah aap ke darjaat buland kare aameen
 

Sohraab

Prime Minister (20k+ posts)
یہ بیماری کسی کو بھی کسی بھی عمر میں ہو سکتی ہے ... الله سب کو تندرست و توانا رکھے اور کسی کا محتاج نہ بنائے ... آمین

مجھے ان انجیکشنز کا تو نہیں پتا کہاں سے ملیں گے لیکن اسلام آباد میں قائد اعظم انٹرنیشنل ہسپتال میں ایک ارتھیو پیڈک سرجن ہیں ڈاکٹر خالد اسلم ، وہ بہت اچھی تشخیص اور علاج کرتے اس مرض کا

میری پھوپھی زاد ہمشیرہ کا بہت مسلہ تھا اور کافی عرصے سے چلتا آ رہا تھا ، ان کا ہم نے تقریباً تمام چھوٹے بڑے ہسپتالوں سے علاج کروایا مگر کوئی فرق نہ پڑا ... کچھ ماہ قابل ڈاکٹر خالد اسلم کا کسی نے ریفرینس دیا ، وہاں گئے انہوں نے گھٹنے میں انجکشن لگائے تو اب ماشاللہ وہ بلکل ٹھیک ہیں ، چل پھر سکتی ہیں

یہ انجیکسشن ہے مہنگا مگر کام ٹھیک کرتا ہے

اگر ممکن ہو تو ان کو ایک دفع چیک کروا لیں شاید کچھ فرق پڑ جائے

ORTHOPEDIC SURGERY

ایک اور بات بھی بتا دوں اس مرض کا کوئی مستقل حل نہیں ہے ، کبھی کبھار یہ واپس بھی آ جاتا ہے لیکن زیادہ تر انجیکشنز سے ٹھیک ہو جاتا ہے

میں یہاں ایک میڈیکل رپورٹ کا انتظار کر رہا ہوں ، اس میں بھی کچھ ایسی ہی بیماری کا علاج درج ہو گا ... اگر مجھے مل گئی تو میں آپ کو انجکشن کا نام بھی بتا دوں گا جو یہاں یو کے میں چل رہا ہے
Injection ka naam phir bata dain apni Relitive se pooch kar , Shukria
 

Humi

Prime Minister (20k+ posts)
That is great news :clap
I hope it is affordable enough for everyone who needs it. If a cure exists, people should not be made to suffer just because they are poor.
No one's profits are worth more than decreasing someone's pain.
 

LovePK-or-LeavePK

Senator (1k+ posts)
Stop fooling yourself.

If this Muslim doctor was not part of that western medical system, he won't invent shit.

Look at dumb Arabs who have unlimited resources but yet to invent a single tablet or do some serious medical research.
 

Kingfisher

Minister (2k+ posts)
Stop fooling yourself.

If this Muslim doctor was not part of that western medical system, he won't invent shit.

Look at dumb Arabs who have unlimited resources but yet to invent a single tablet or do some serious medical research.

Yes from last almost 150 years their system did stop innovations.. but..
But if you go beyond that they were ruling more than half of the Globe as Ottomans and as Mughals from the last 1000 years.
Muslims innovations in Medical science will never be forgotton and Librarries will never be for gotton

Pakistan Innovation in war fare, atomic weapons are far more superior than our neighbors and Pakistan is the only country to achieve that power and is now doing it independently.
Pakistan AlKhalid Tanks are one of the best and superior in the entire Region.
Pakistan JF thunder planes are excellent innovation too


Muslims started loosing because most corrupt and incapable people came on the top, like Nawaz Sharif and his entire team
Pakistan will soon get on track under leadership of "Imran Khan"

From Oil Rich Arabs .. you cannot expect that as they got wealth without doing any hard work. Easy come, easy go...
 
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Aslan

Chief Minister (5k+ posts)
Stop fooling yourself.

If this Muslim doctor was not part of that western medical system, he won't invent shit.

Look at dumb Arabs who have unlimited resources but yet to invent a single tablet or do some serious medical research.
If you look back in history the Arabs and muslims invented my things eg the surgical instruments used today are almost same as those invented in the 10th century by al-Zahrawi.Unfortunately after the decline of muslim power research in science and technologoly was not promoted.The people are not dumb,it is the rulers who are dumb.They became hedonistic ie they lived for personal pleasure.The oil rich Arab countries did not invest in science and technology fifty years ago.Their priorty was skyscrapers,hotels,palaces,big highways and keeping their money in the west.Their is no R&D culture in these countries.Saudi Arabia is trying to invest in human resources.It has built a few good universities but it is very slow.R&D needs a lot of money skilled manpower which many countries don't have. China which is a big countries is just beginning to catch up with the west.America took manpower from almsot every corner of the globe to help it become a leading power.
 

Sunbeam

Senator (1k+ posts)
If you look back in history the Arabs and muslims invented my things eg the surgical instruments used today are almost same as those invented in the 10th century by al-Zahrawi.Unfortunately after the decline of muslim power research in science and technologoly was not promoted.The people are not dumb,it is the rulers who are dumb.They became hedonistic ie they lived for personal pleasure.The oil rich Arab countries did not invest in science and technology fifty years ago.Their priorty was skyscrapers,hotels,palaces,big highways and keeping their money in the west.Their is no R&D culture in these countries.Saudi Arabia is trying to invest in human resources.It has built a few good universities but it is very slow.R&D needs a lot of money skilled manpower which many countries don't have. China which is a big countries is just beginning to catch up with the west.America took manpower from almsot every corner of the globe to help it become a leading power.
Excellent reply and comments ..
 

Sunbeam

Senator (1k+ posts)
Yes from last almost 150 years their system did stop innovations.. but..
But if you go beyond that they were ruling more than half of the Globe as Ottomans and as Mughals from the last 1000 years.
Muslims innovations in Medical science will never be forgotton and Librarries will never be for gotton

Pakistan Innovation in war fare, atomic weapons are far more superior than our neighbors and Pakistan is the only country to achieve that power and is now doing it independently.
Pakistan AlKhalid Tanks are one of the best and superior in the entire Region.
Pakistan JF thunder planes are excellent innovation too


Muslims started loosing because most corrupt and incapable people came on the top, like Nawaz Sharif and his entire team
Pakistan will soon get on track under leadership of "Imran Khan"

From Oil Rich Arabs .. you cannot expect that as they got wealth without doing any hard work. Easy come, easy go...

Good one.
Pakistan was looking for a Leader like Imran khan no doubt and will Florish IA.
 

LovePK-or-LeavePK

Senator (1k+ posts)
If you look back in history the Arabs and muslims invented my things eg the surgical instruments used today are almost same as those invented in the 10th century by al-Zahrawi.Unfortunately after the decline of muslim power research in science and technologoly was not promoted.The people are not dumb,it is the rulers who are dumb.They became hedonistic ie they lived for personal pleasure.The oil rich Arab countries did not invest in science and technology fifty years ago.Their priorty was skyscrapers,hotels,palaces,big highways and keeping their money in the west.Their is no R&D culture in these countries.Saudi Arabia is trying to invest in human resources.It has built a few good universities but it is very slow.R&D needs a lot of money skilled manpower which many countries don't have. China which is a big countries is just beginning to catch up with the west.America took manpower from almsot every corner of the globe to help it become a leading power.


First of all stop using what happened many centuries ago just as an excuse for Mulim's failure today. Some basic know how on basic things many centuries ago don't mean shit today.

It's like all muslims keeps talking about golden age of Khilafat while truth is that 3 out of 4 Caliphs were murdered by own Muslims!!!! Arabs must be really peaceful people people

Secondly, Arabs and Muslims are actually dumb people with no compassion or humanity left in them and that is why their leaders are dumb.

After Muhammad (PBUH) Muslims became violent people. They forgot all about his teachings of peace. They even slaughtered family of Prophet (PBUH). Perhaps that is the reason they are all cursed by Allah for forever.

You mentioned China. They gained independence in 1948 only and they never had any free oil wealth like these arabs. Even they are doing much better than these dumb Muslim countries.

Yes, American harvest brain from all over the world and considers youth as their strength. But these dumb Arab and Muslim countries refuse to even give education to kids's of foreigners. Let alone any major research grants for medicine.

Pakistanis work all their lives like slaves in Saudi Arab and help their economy flourish but their kids have to return to Pakistan because Saudi Universities can't even give them free education. This is the fine example of attitude and behavior of Muslims today.

That is why let's just stop fantasizing past and tell the world what you have to offer for future. No one believes today that Islam & Muslims are peaceful or law-abiding, or justice & equality loving people.
 

Kingfisher

Minister (2k+ posts)
First of all stop using what happened many centuries ago just as an excuse for Mulim's failure today. Some basic know how on basic things many centuries ago don't mean shit today.

It's like all muslims keeps talking about golden age of Khilafat while truth is that 3 out of 4 Caliphs were murdered by own Muslims!!!! Arabs must be really peaceful people people

Secondly, Arabs and Muslims are actually dumb people with no compassion or humanity left in them and that is why their leaders are dumb.

After Muhammad (PBUH) Muslims became violent people. They forgot all about his teachings of peace. They even slaughtered family of Prophet (PBUH). Perhaps that is the reason they are all cursed by Allah for forever.

You mentioned China. They gained independence in 1948 only and they never had any free oil wealth like these arabs. Even they are doing much better than these dumb Muslim countries.

Yes, American harvest brain from all over the world and considers youth as their strength. But these dumb Arab and Muslim countries refuse to even give education to kids's of foreigners. Let alone any major research grants for medicine.

Pakistanis work all their lives like slaves in Saudi Arab and help their economy flourish but their kids have to return to Pakistan because Saudi Universities can't even give them free education. This is the fine example of attitude and behavior of Muslims today.

That is why let's just stop fantasizing past and tell the world what you have to offer for future. No one believes today that Islam & Muslims are peaceful or law-abiding, or justice & equality loving people.

Why there is always shit in your mouth you covv piiss drinker .. We know you are short of toilets there. Now your answer is there are mushriqs everywhere and they have killed their rulers even they were great, we have Mir Jaffers and Mir Sadiqs like every Society and religion. If you read any history independent of any religions, people got killed for Power. Take example of current N Koren king, he killed his own brother ..

You are totally wrong that Arabs are dumb, only orich Arabs are dumb and who are oil rich because got wealth without any effort but overall Arabs are very hardworking people , now localization is taking place in Arab and these educated ones are talented.

Regarding China, anwer to this is Pakistan had Surpassed China and all Asian countries under President Gen Ayub Khan rule , go and read history, it is just the leadership which matters.

Regarding Education it is given by rulers policies which was not in priority list of Nawaz Sharif Govt .

In Saudi and other gulf countries not Pakistan only, Indians, Bangladeshi and Srilanks all like Slaves for money and it is their policy which is same for all not to give nationalities . Most of western countries are also giving nationality on Skills basis as they need people to work whereas Gulf countires have their own enough jobless people .